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Psychoactive substance use - Psychoactive substances in general can be used as tools for psychonautics, depending on the intent and outcome. However, hallucinogens make up the majority of substances used for the purpose of psychonautics. These typically include naturally occurring, plant-based psychedelic such as peyote, ibogaine, psilocybin mushrooms, LSA and DMT (in the form of ayahuasca), although they can also include semisynthetic compounds such as LSD. Dissociatives such as ketamine, dextromethorphan and atypical psychedelics such as Amanita muscaria and Salvia divinorum are sometimes used as well. Those who attribute extra-worldly, religious, or spiritual significance to these substances may refer to them as entheogens ("generating the divine within").

The contents of this index are based on the collective experiences of our contributors and various anecdotal reports collected from the internet. A curated archive of some of these reports can be found in our experience index.

Naturally occurring sources refers to psychoactive chemicals or their precursors that already exist in nature. This is in contrast to synthetic psychoactive compounds which are artificially produced or designed in laboratories. These natural chemicals can often be reproduced synthetically as well, though notably they appear in nature or through human cultivation.

Below is an index of articles regarding natural sources of psychoactive substances. Other than inanimate sources they are categorized by kingdom of organism with sections for each applicable class of psychoactivity, sub-sections are given to active constituents, and finally the taxonomy and common name. Names may appear more than once if they contain a variety of substances, or their active substance has a variety of effects. Please note the quantity of substance obtained through an organism is not always safe and/or effective at common levels of consumption, but they are here included for sake of completeness. In addition some of the organisms are toxic or dangerous and thus proper research and preparation is recommended before attempting to personally investigate their activity.

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